Two Cases of Neuroendocrine Carcinoma and GIST in a Patient with Neurofibromatosis Type 1.
- Author:
Wonyoung CHOI
1
;
Seung Dok HONG
;
Ha Na KIM
;
Yoo Duk CHOI
;
Jun Eul HWANG
;
Hyun Jeong SHIM
;
Woo Kyun BAE
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. drwookyun@jnu.ac.kr
- Publication Type:Case Report
- Keywords:
Neurofibromatosis type 1;
Gastrointestinal stromal tumor;
Neuroendocrine carcinoma
- MeSH:
Carcinoid Tumor;
Carcinoma, Neuroendocrine;
Duodenum;
Gastrointestinal Stromal Tumors;
Gastrointestinal Tract;
Humans;
Jejunum;
Neurofibromatoses;
Neurofibromatosis 1;
Neuroma
- From:Korean Journal of Medicine
2011;81(6):786-791
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Patients with neurofibromatosis type 1 (NF1) are at increased risk of developing tumors throughout the gastrointestinal tract, including neuromas, gastrointestinal stromal tumors (GISTs), and periampullary somatostatin-rich carcinoids. The simultaneous occurrence of a GIST and a well-differentiated neuroendocrine carcinoma in a patient with NF1 is very rare. Here, we report two cases of the coexistence of a low-risk GIST in the jejunum with a well-differentiated neuroendocrine carcinoma in the duodenum in patients with NF1. These cases strengthen the known association of GIST with neuroendocrine carcinoma in patients with NF1.
