The Relationship Between Serum Total Bilirubin and Framingham Risk Score in Healthy Korean Men.
- Author:
Hyejin CHUN
1
;
Sang Wha LEE
;
Yukyung CHOI
;
Hong Soo LEE
;
Kyung Won SHIM
Author Information
1. Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea. fmewha@naver.com
- Publication Type:Original Article
- Keywords:
Total bilirubin;
Framingham risk score;
Cardiovascular disease
- MeSH:
Ambulatory Care Facilities;
Bilirubin;
Blood Pressure;
Cardiovascular Diseases;
Cholesterol;
Health Promotion;
Humans;
Linear Models;
Lipoproteins;
Male;
Risk Factors;
Smoke;
Smoking
- From:Korean Journal of Health Promotion
2013;13(1):1-7
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Serum total bilirubin has been considered a harmful substance inducing oxidative reaction; but recently, there have been reports of it possessing antioxidative, anti-inflammatory and protective features against cardiovascular diseases. The purpose of this study was to investigate the relationship between total bilirubin and the Framingham risk score. METHODS: This study involved 3,414 healthy Korean men who underwent a medical check-up in a health promotion center in 2008. We calculated the Framingham risk score using age, smoking status, systolic blood pressure, total cholesterol and high-density lipoprotein cholesterol. RESULTS: The mean age of the participants was 44.9+/-8.8 years. The log transformed serum total bilirubin level and the Framingham risk score had a negative linear relationship in a simple linear regression analysis (R2: 0.018, P<0.001). In a multivariable analysis model, as well, the log transformed serum total bilirubin level and the Framingham risk score had a negative linear relationship (R2: 0.384, P<0.001). CONCLUSIONS: Our study showed a statistically significant negative relationship between total bilirubin and the Framingham risk score. Total bilirubin had a stronger relationship with the Framingham risk score than other standard cardiovascular risk factors except smoking, and thus may be useful in predicting cardiovascular risk in the outpatient clinic.
