Seventy-two hour peri-operative volume replacement with 6% HES 130/0.4 vs. 20% albumin in patients undergoing abdominal, cranial, and orthopedic surgery.
- Author:
Dong Hee KIM
1
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Dankook University, Cheonan, Korea. ybs90@unitel.co.kr
- Publication Type:Original Article
- Keywords:
albumin;
cardiac index;
high risk surgery;
hydroxyethylstarch;
volume replacement
- MeSH:
Blood Coagulation;
Gases;
Hemodynamics;
Humans;
Orthopedics;
Oxygen
- From:Anesthesia and Pain Medicine
2009;4(3):235-241
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND:This study was designed to compare hydroxyethylstarch (HES) to albumin in high-risk surgery patients infused over 72 h peri-operatively; hemodynamic changes, oxygen transport parameters, blood gases, blood coagulation, blood loss, blood use, outcome, and costs were compared. METHODS:High-risk surgical patients undergoing high-risk abdominal, cranial, and orthopaedic surgery were treated with 6% HES (130/0.4; n = 41) or 20% albumin (n = 19).The goal of volume therapy was to maintain a normal cardiac index (CI; 3.0 L/min/m2) over 72 h peri-operatively. RESULTS:The hemodynamic and cardiac effects of 6% HES were superior to 20% albumin.HES reduced disturbances in blood coagulation, blood loss, and blood use as compared to albumin. Volume therapy with HES and albumin improved patient outcomes.Use of HES resulted in a significant cost reduction compared to albumin. CONCLUSIONS:Volume replacement with 6% HES and 20% albumin in surgery over 72 h peri-operatively improved hemodynamic parameters and oxygen transport to normal values.HES provides a cost-effective alternative to albumin in surgery with improved efficacy and safety.
