Small Flat Adenocarcinoma of the Colon Arising From Familial Adenomatous Polyposis Patient: Suggesting de novo Origin.
- Author:
Dong Kook PARK
;
Min Chol LEE
;
Ho Jin JUN
;
Chan Young LEE
;
Jung Tak KIM
;
Min JUNG
;
Jong Kwon PARK
;
Jin Woo RYU
- Publication Type:Original Article
- Keywords:
Small flat adenocarcinoma;
Colon
- MeSH:
Adenocarcinoma*;
Adenoma;
Adenomatous Polyposis Coli*;
Adenomatous Polyps;
Carcinogenesis;
Colon*;
Colonic Neoplasms;
Colorectal Neoplasms;
Epithelial Cells;
Epithelium;
Humans;
Lymph Nodes;
Neoplasm Metastasis
- From:Journal of the Korean Society of Coloproctology
1998;14(3):655-660
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells. Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.
