Levels of Soluble Interleukin-2 Receptors in Serum of Patients with Behçet's Disease.
10.5021/ad.1993.5.1.13
- Author:
Won HUR
;
Seung Hun LEE
;
Dongsik BANG
;
Sungnack LEE
;
Jung Chul KIM
;
Tai Ho CHUNG
- Publication Type:Original Article
- Keywords:
Behçet's disease;
Soluble interleukin-2 receptor
- MeSH:
Autoimmune Diseases;
Enzyme-Linked Immunosorbent Assay;
Humans;
Interleukin-2*;
Lymphocyte Activation;
Lymphocytes;
Methods;
Receptors, Interleukin-2*
- From:Annals of Dermatology
1993;5(1):13-16
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Interleukin-2 receptor (IL-2) is expressed and released predominantly activated T lymphocyte. Increased serum levels of soluble IL-2R have been noted in a variety of autoimmune diseases and in conditions associated with T lymphocyte activation. OBJECTIVE: We aimed to examine whether the T lymphocyte activation has any association with the pathogenesis of Behçet's disease. METHOD: We have measured the serum level of soluble IL-2R in serum samples obtained from 67 patients with Behçet's disease and 30 healthy people as a control group, using a double-antibody sandwich enzyme-linked immunosorbent assay technique. RESULTS: Serum soluble IL-2R levels were found to be significantly elevated in the group of Behçet's disease as compared with the control group. No significant differences were found within clinical subtypes of Behçet's disease. CONCLUSION: These findings suggest the presence of an ongoing T lymphocyte activation in this disease process.
