Association between Kawasaki disease and acute respiratory viral infections.
10.3345/kjp.2009.52.11.1241
- Author:
Eun Young CHO
1
;
Byung Wook EUN
;
Nam Hee KIM
;
Jina LEE
;
Eun Hwa CHOI
;
Hoan Jong LEE
;
Jung Yun CHOI
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. eunchoi@snu.ac.kr
- Publication Type:Original Article ; Multicenter Study
- Keywords:
Kawasaki disease;
Respiratory tract infections;
Human coronavirus
- MeSH:
Adenoviridae;
Coinfection;
Coronavirus NL63, Human;
Human bocavirus;
Humans;
Immunoglobulins;
Metapneumovirus;
Mucocutaneous Lymph Node Syndrome;
Orthomyxoviridae;
Paramyxoviridae Infections;
Respiratory Syncytial Viruses;
Respiratory Tract Infections;
Retrospective Studies;
Rhinovirus
- From:Korean Journal of Pediatrics
2009;52(11):1241-1248
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The etiology of Kawasaki disease (KD) is still unknown. Recently, an association between human coronavirus NL63 (HCoV-NL63) and KD was implicated. Hence, we attempted to determine the association between KD and acute respiratory viral infections. METHODS: Nasopharyngeal aspirate samples were obtained from 54 patients diagnosed with KD at the Seoul National University (SNU) Children's Hospital and SNU-Bundang Hospital between October 2003 and September 2006. Viral diagnoses of 11 respiratory viruses were made using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR): respiratory syncytial virus (RSV), adenovirus, rhinovirus (RV), parainfluenza viruses (PIVs) 1 and 3, influenza viruses (IFVs) A and B, human metapneumovirus (HMPV), human bocavirus (HBoV), HCoV OC43/229E, and HCoV-NL63. Clinical data were reviewed retrospectively. RESULTS: The median age was 32 months (6 months-10.4 years). Respiratory symptoms were observed in 37 patients (69%). The following respiratory viruses were identified in 12 patients (22%): RV (n=4), PIV-3 (n=2), HBoV (n=2), and adenovirus, RSV, PIV-1, IFV-A, and HCoV-NL63 (n=1). Co-infection with PIV-3 and RV was observed in one patient. Respiratory symptoms were observed in 7 (58.3%) and 30 (71.4%) patients of the virus-positive and virus-negative groups (P>0.05). Response rate to intravenous immunoglobulin administration was 67% (n=8) and 86% (n=36) in the virus-positive and virus-negative groups (P>0.05). CONCLUSION: Respiratory symptoms were commonly observed in KD patients but the association between respiratory viruses and KD were not found. Large multicenter-based investigations are required to confirm the association between acute respiratory viral infections and KD.
