Multicenter clinical study of childhood periodic syndromes that are common precursors to migraine using new criteria of the International Classification of Headache Disorders (ICHD-II).
10.3345/kjp.2009.52.5.557
- Author:
Jae Yong PARK
1
;
Sang Ook NAM
;
So Hee EUN
;
Su Jeong YOU
;
Hoon Chul KANG
;
Baik Lin EUN
;
Hee Jung CHUNG
Author Information
1. Department of Pediatrics, National Health Insurance Corporation, Ilsan Hospital, Korea. agathac@nhimc.or.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Childhood periodic syndrome;
Migraine headache;
Cyclic vomiting syndrome;
Abdominal migraine;
Benign paroxysmal vertigo of childhood
- MeSH:
Abdominal Pain;
Child;
Dizziness;
Headache;
Headache Disorders;
Humans;
Incidence;
Korea;
Longitudinal Studies;
Migraine Disorders;
Neurology;
Resin Cements;
Vertigo;
Vomiting
- From:Korean Journal of Pediatrics
2009;52(5):557-566
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the clinical features and characteristics of childhood periodic syndromes (CPS) in Korea using the new criteria of the International Classification of Headache Disorders (ICHD)-II. METHODS: The study was conducted at pediatric neurology clinics of five urban tertiary-care medical centers in Korea from January 2006 to December 2007. Patients (44 consecutive children and adolescents) were divided into three groups (cyclic vomiting syndrome [CVS], abdominal migraine [AM], and benign paroxysmal vertigo of childhood [BPVC]) by recurrent paroxysmal episodes of vomiting, abdominal pain, dizziness, and/or vertigo using the ICHD-II criteria and their characteristics were compared. RESULTS: Totally, 16 boys (36.4%) and 28 girls (63.6%) were examined (aged 4-18 yr), with 20 CVS (45.5%), 8 AM (18.2%), and 16 BPVC (36.4%) patients. The mean age at symptom onset was 6.3+/-3.6 yr, 8.5+/-2.7 yr, and 8.5+/-2.9 yr in the CVS, AM, and BPVC groups, respectively, showing that symptoms appeared earliest in the CVS group. The mean age at diagnosis was 8.0+/-3.4 yr, 10.5+/-2.6 yr, and 10.1+/-3.2 yr the CVS, AM, and BPVC groups, respectively. Of the 44 patients, 17 (38.6%) had a history of recurrent headaches and 11 (25.0%) showed typical symptoms of migraine headache, with 5 CVS (25.0%), 2 AM (25.0%), and 4 BPVC (25.0%) patients. Family history of migraine was found in 9 patients (20.4%): 4 in the CVS group (20.0%), 2 in the AM group (25.0%), and 3 in the BPVC group (18.8%). CONCLUSION: The significant time lag between the age at symptom onset and final diagnosis possibly indicates poor knowledge of CPS among pediatric practitioners, especially in Korea. A high index of suspicion may be the first step toward caring for these patients. Furthermore, a population-based longitudinal study is necessary to determine the incidence and natural course of these syndromes.
