Renal intercalated cells and blood pressure regulation.
10.23876/j.krcp.2017.36.4.305
- Author:
Susan M WALL
1
Author Information
1. Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. smwall@emory.edu
- Publication Type:Review
- Keywords:
Blood pressure;
Cl⁻/HCO⁻− exchange;
Epithelial sodium channels;
Intercalated cells;
Pendrin;
Slc26a4
- MeSH:
Absorption;
Acid-Base Equilibrium;
Adrenal Medulla;
Aldosterone;
Alkalosis;
Angiotensin II;
Angiotensins;
Blood Pressure*;
Catecholamines;
Epithelial Sodium Channels;
Negotiating;
Nephrons;
Rodentia
- From:Kidney Research and Clinical Practice
2017;36(4):305-317
- CountryRepublic of Korea
- Language:English
-
Abstract:
Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate Cl⁻ absorption and HCO₃⁻ secretion largely through pendrin-dependent Cl⁻/HCO₃⁻ exchange. This exchange is stimulated by angiotensin II administration and is also stimulated in models of metabolic alkalosis, for instance after aldosterone or NaHCO₃ administration. In some rodent models, pendrin-mediated HCO₃⁻ secretion modulates acid-base balance. However, the role of pendrin in blood pressure regulation is likely of more physiological or clinical significance. Pendrin regulates blood pressure not only by mediating aldosterone-sensitive Cl⁻ absorption, but also by modulating the aldosterone response for epithelial Na⁺ channel (ENaC)-mediated Na⁺ absorption. Pendrin regulates ENaC through changes in open channel of probability, channel surface density, and channels subunit total protein abundance. Thus, aldosterone stimulates ENaC activity through both direct and indirect effects, the latter occurring through its stimulation of pendrin expression and function. Therefore, pendrin contributes to the aldosterone pressor response. Pendrin may also modulate blood pressure in part through its action in the adrenal medulla, where it modulates the release of catecholamines, or through an indirect effect on vascular contractile force. This review describes how aldosterone and angiotensin II-induced signaling regulate pendrin and the contributory role of pendrin in distal nephron function and blood pressure.
