The experimental study of the bone regeneration on rabbit maxillary sinus grafting with beta-TCP.
- Author:
Jung Ha PARK
1
;
Kyung Gyun HWANG
;
Chang Joo PARK
;
Yong Soo CHOI
;
Pyung Soo MA
;
Seung Sam PAIK
;
Kwang Sup SHIM
Author Information
1. Division of Oral and Maxillofacial Surgery, Department of Dentstry, College of Medicine Hanyang University, Korea. hkg@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
beta-TCP;
Rabbit;
Maxillary sinus
- MeSH:
Bone Regeneration*;
Maxillary Sinus*;
Membranes;
Osteogenesis;
Rabbits;
Regeneration;
Transplants*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2006;32(2):107-116
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:Maxillay sinus grafting is an effective treatment procedure to improve bone height in the posterior maxillar area for implant installation. Beta-tricalciumphosphate(beta-TCP) was introduced to be grafting substitute material, providing a reasonable bio-degradation time, no need for harvesting procedure. The purpose of this study is to evaluate bone healing and regeneration phase using histomorphometric and immunohistochemical analysis. MATERIAL AND METHODS:Sixteen rabbits were divided into 4 groups. Bi-lateral maxillary sinus membranes were elevated at each rabbits, beta-TCP was augmented in left sinus, autogenous bone was augmented in right sinus. The rabbits were sacrificed at 2, 4, 8 and 12 weeks. We investigated the bone regeneration and growth factor expression. RESULTS: 1. The mean new bone volume formation was 28.99+/-6.55%, 49.54+/-5.47%, 69.09+/-8.90% in autogenous grafted area, and 22.86+/-5.56%, 24.00+/-4.09%, 34.11+/-3.37% in beta-TCP area at 4, 8, 12 weeks. Therefore, new bone formation in autogenous bone was significantly higher than beta-TCP (p<0.05). 2. The BMP 2/4 expression in autogenous bone grafted area was higher at 4, 8 weeks. 3. There was no difference in expression pattern of BMP-7/PDGF/VEGF during grafted bone regeneration. CONCLUSION:The authors we conclude that the autogenous bone graft was faster than beta-TCP in bone regeneration, and the BMP 2/4 were more important in graft bone regeneration.
