Immunogenicity of MenACWY-CRM in Korean Military Recruits: Influence of Tetanus-Diphtheria Toxoid Vaccination on the Vaccine Response to MenACWY-CRM.
10.3349/ymj.2016.57.6.1511
- Author:
Han Wool KIM
1
;
In Ho PARK
;
Sooseong YOU
;
Hee Tae YU
;
In Soo OH
;
Pil Soo SUNG
;
Eui Cheol SHIN
;
Kyung Hyo KIM
Author Information
1. Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. kaykim@ewha.ac.kr
- Publication Type:Brief Communication
- Keywords:
Neisseria meningitidis;
serum bactericidal antibody assay;
meningococcal vaccine
- MeSH:
Complement System Proteins;
Humans;
Immunization;
Korea;
Meningococcal Vaccines;
Military Personnel*;
Neisseria meningitidis;
Serogroup;
Serum Bactericidal Antibody Assay;
Toxoids;
Vaccination*
- From:Yonsei Medical Journal
2016;57(6):1511-1516
- CountryRepublic of Korea
- Language:English
-
Abstract:
The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.
