Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction.
10.3346/jkms.2010.25.10.1456
- Author:
Min Goo LEE
1
;
Myung Ho JEONG
;
Youngkeun AHN
;
Shung Chull CHAE
;
Seung Ho HUR
;
Taek Jong HONG
;
Young Jo KIM
;
In Whan SEONG
;
Jei Keon CHAE
;
Jay Young RHEW
;
In Ho CHAE
;
Myeong Chan CHO
;
Jang Ho BAE
;
Seung Woon RHA
;
Chong Jin KIM
;
Donghoon CHOI
;
Yang Soo JANG
;
Junghan YOON
;
Wook Sung CHUNG
;
Jeong Gwan CHO
;
Ki Bae SEUNG
;
Seung Jung PARK
Author Information
1. The Heart Center of Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article ; Evaluation Studies
- Keywords:
Metabolic Syndrome;
Prognosis;
Myocardial Infarction
- MeSH:
Acute Disease;
Age Factors;
Aged;
C-Reactive Protein/analysis;
Cholesterol, LDL/blood;
Coronary Angiography;
Female;
Humans;
Male;
Metabolic Syndrome X/*complications/epidemiology;
Middle Aged;
Multivariate Analysis;
Myocardial Infarction/*complications/mortality/therapy;
Predictive Value of Tests;
Prognosis;
Treatment Outcome;
Ventricular Dysfunction, Left/complications/physiopathology
- From:Journal of Korean Medical Science
2010;25(10):1456-1461
- CountryRepublic of Korea
- Language:English
-
Abstract:
We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8+/-12.3 yr); group II: Non-MS (n=808, 675 men, 64.2+/-13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (P=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (P=0.01). The incidence of in-hospital death was higher in group I than in group II (P=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.
