Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males.
10.3346/jkms.2010.25.10.1480
- Author:
Seong Yong LIM
1
;
Eun Jung RHEE
;
Ki Chul SUNG
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Insulin Resistance;
Lung Function;
Metabolic Syndrome;
Obesity;
Systemic Inflammation
- MeSH:
Adult;
C-Reactive Protein/analysis;
Forced Expiratory Volume/physiology;
Glucose/metabolism;
Humans;
Inflammation/complications/*physiopathology;
Insulin/blood;
*Insulin Resistance;
Male;
Metabolic Syndrome X/complications/*physiopathology;
Middle Aged;
Obesity/complications;
Odds Ratio;
Pulmonary Ventilation/*physiology;
Republic of Korea;
Respiratory Function Tests;
Risk Factors;
Vital Capacity/physiology
- From:Journal of Korean Medical Science
2010;25(10):1480-1486
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used to assess IR. The presence of MetS was defined according to the AHA/NHLBI criteria. The prevalence of MetS was 19.3%. The odds ratio of MetS for restrictive ventilatory pattern was 1.55 (95% confidence interval, 1.12-2.14), and that for obstructive ventilatory pattern was 1.39 (0.66-2.94) after adjustment for confounders. When subjects were divided in 4 groups according to quartiles of FVC or FEV1 (% predicted [pred]), HOMA-IR significantly increased as the FVC or FEV1 (% predicted [pred]) decreased. Individuals in the lowest FVC or FEV1 quartile had the highest hs-CRP level. Prevalence of MetS increased as FVC or FEV1 (% predicted [pred]) quartiles decreased. The abdominal obesity, hs-CRP and HOMA-IR were the independent predictors for the lowest FVC and FEV1 (% predicted [pred]) even after adjustment for confounders. These results indicate that MetS, IR, and systemic inflammation are important risk factors for reduced lung function in nonsmoking Korean males.
