A Case of Congenital Hypopituitarism with Anterior Pituitary Hypoplasia and Ectopic Posterior Pituitary Gland.
- Author:
Young Joo SON
1
;
Hong Sun PARK
;
Kye Shik SHIM
;
Kyuchul CHOEH
;
Tae Il HAN
Author Information
1. Department of Pediatrics, Eulji Medical College, Taejon, Korea.
- Publication Type:Case Report
- Keywords:
Congenital hypopituitarism;
Anterior pituitary hypoplasia;
Ectopic posterior pituitary gland
- MeSH:
Brain;
Child;
Female;
Genitalia;
Growth Hormone;
Humans;
Hyperinsulinism;
Hypoglycemia;
Hypopituitarism*;
Hypothalamus;
Infant, Newborn;
Jaundice;
Magnetic Resonance Imaging;
Pituitary Gland;
Pituitary Gland, Anterior;
Pituitary Gland, Posterior*;
Sexual Maturation;
Tuber Cinereum
- From:Journal of the Korean Pediatric Society
1999;42(12):1746-1750
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pituitary gland develops from two different parts of the brain. The anterior pituitary gland originates from the Rathke pouch and the posterior one from the infundibulum. Therefore, the pathologic findings of congenital hypopituitarism can be different in each case. Congenital hypopituitarism is a rare disorder. The characteristic clinical features of the affected newborns are prolonged jaundice, persistent or recurrent hypoglycemia without hyperinsulinism and microphallus. Their genitalia are usually underdeveloped and sexual maturation may be delayed or absent. In adulthood, patients retain childish feature, short stature with normal body proportion. We experienced a case of congenital hypopituitarism in a 12-year-old female patient with short stature and delayed sexual maturation(Tanner stageI). The endocrinological studies revealed growth hormone, FSH, LH and TSH deficiencies. Magnetic resonance imaging indicated a hypoplastic anterior pituitary and an ectopic posterior pituitary gland located within the tuber cinereum of the hypothalamus.
