The Usefulness of F18-FDG PET/CT in Detection of Colonic Neoplasm.
- Author:
Min Kyung KANG
1
;
Sung Pyo HONG
;
Ji Eun LEE
;
Tae Joo JEON
;
Jong Woo KIM
;
Chang Il KWON
;
Kwang Hyun KO
;
Seong Gyu HWANG
;
Pil Won PARK
;
Kyu Sung RIM
Author Information
- Publication Type:Original Article
- Keywords: PET/CT; Colonoscopy; Colonic Neoplasms
- MeSH: Adenoma; Colon; Colonic Neoplasms; Colonoscopy; Endoscopy; Humans; Male; Mass Screening; Nuclear Medicine; Polyps; Positron-Emission Tomography; Retrospective Studies; Sensitivity and Specificity; Specialization
- From:Intestinal Research 2010;8(1):18-23
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The diagnostic value of 2-18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET)/CT in the detection of colon carcinoma and adenoma was evaluated retrospectively. METHODS: Between May 2007 and June 2008, 102 patients (42 males and 60 females: age range, 28-89 years) underwent both FDG PET/CT and colonoscopy in < a 3 month interval. FDG uptake on PET/CT was divided into physiologic and pathologic uptake by a nuclear medicine specialist. Pathologic confirmation was obtained in all patients. RESULTS: Forty-three patients had no abnormal findings on both FDG PET/CT and colonoscopy. One hundred five and 59 colonic lesions were detected on FDG PET/CT and colonoscopy, respectively. Eleven of 24 lesions with pathologic FDG uptake were histologically-confirmed to be malignancies. Among 18 lesions with physiologic FDG uptake, 1 carcinoma and 1 adenoma were revealed. One carcinoma, 25 adenomas, and 11 hyperplastic polyps did not reveal FDG uptake. Interpretation of pathologic FDG uptake in the colon had a sensitivity of 84.6% and 28.2%, a specificity of 90.4% and 88.1%, a positive predictive value of 45.8% and 45.8%, and a negative predictive value of 98.4% and 77.8% for carcinomas and adenomas, respectively. CONCLUSIONS: FDG PET/CT is a very useful diagnostic method for the detection of colon cancer, but the sensitivity is low for adenomas, which may need further evaluation, such as a screening endoscopy.
