The Clinical Significance of Normal Mammograms and Normal Sonograms in Patients with Palpable Abnormalities of the Breast.
10.3348/jkrs.2006.55.3.299
- Author:
Jin Hwa LEE
1
;
Eun Kyung KIM
;
Seong Kuk YOON
;
Sunseob CHOI
;
Kyung Jin NAM
;
Se Heon CHO
;
Dae Cheol KIM
;
Jung Il KIM
Author Information
1. Department of Diagnostic Radiology, College of Medicine, Dong-A University, Korea. jhrad@dau.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Breast US;
Breast radiography, comparative studies;
Breast, abnormalities;
Biopsies
- MeSH:
Biopsy;
Breast Neoplasms;
Breast*;
Female;
Follow-Up Studies;
Humans;
Mammography;
Middle Aged;
Physical Examination;
Referral and Consultation;
Retrospective Studies;
Sample Size;
Subcutaneous Fat;
Ultrasonography
- From:Journal of the Korean Radiological Society
2006;55(3):299-304
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We wanted to evaluate the clinical significance of normal mammograms and normal sonograms in patients with palpable abnormalities of the breast. MATERIALS AND METHODS: From Apr 2003 to Feb 2005, 107 patients with 113 palpable abnormalities who had combined normal sonographic and normal mammographic findings were retrospectively studied. The evaluated parameters included age of the patients, the clinical referrals, the distribution of the locations of the palpable abnormalities, whether there was a past surgical history, the mammographic densities and the sonographic echo patterns (purely hyperechoic fibrous tissue, mixed fibroglandular breast tissue, predominantly isoechoic glandular tissue and isoechoic subcutaneous fat tissue) at the sites of clinical concern, whether there was a change in imaging and/or the physical examination results at follow-up, and whether there were biopsy results. This study period was chosen to allow a follow-up period of at least 12 months. RESULTS: The patients' ages ranged from 22 to 66 years (mean age: 48.8 years) and 62 (58%) of the 107 patients were between 41 and 50 years old (58%). The most common location of the palpable abnormalities was the upper outer portion of the breast (45%) and most of the mammographic densities were dense patterns (BI-RADS Type 3 or 4: 91%). Our cases showed similar distribution for all the types of sonographic echo patterns. 23 patients underwent biopsy; all the biopsy specimens were benign. For the 84 patients with 90 palpable abnormalities who were followed, there was no interval development of breast cancer in the areas of clinical concern. CONCLUSION: Our results suggest that we can follow up and prevent unnecessary biopsies in women with palpable abnormalities when both the mammography and ultrasonography show normal tissue, but this study was limited by its small sample size. Therefore, a larger study will be needed to better define the negative predictive value of combined normal sonographic and mammographic findings.
