Regional Difference of Antibiotic Resistance of Helicobacter pylori Strains in Korea.
10.4166/kjg.2011.57.4.221
- Author:
Jae Yeon KIM
1
;
Nayoung KIM
;
Sung Jung KIM
;
Gwang Ho BAIK
;
Gwang Ha KIM
;
Jung Mogg KIM
;
Ryoung Hee NAM
;
Hong Bin KIM
;
Dong Ho LEE
;
Hyun Chae JUNG
;
In Sung SONG
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. nayoungkim49@empal.com
- Publication Type:Original Article ; English Abstract ; Research Support, Non-U.S. Gov't
- Keywords:
Helicobacter pylori;
Antibiotic resistance
- MeSH:
Amoxicillin/pharmacology;
Anti-Bacterial Agents/pharmacology/therapeutic use;
Aza Compounds/pharmacology;
Azithromycin/pharmacology;
Ciprofloxacin/pharmacology;
Clarithromycin/pharmacology;
*Drug Resistance, Bacterial;
Female;
Helicobacter Infections/*epidemiology/microbiology;
Helicobacter pylori/*drug effects/isolation & purification;
Humans;
Male;
Metronidazole/pharmacology;
Microbial Sensitivity Tests;
Middle Aged;
Ofloxacin/pharmacology;
Quinolines/pharmacology;
Republic of Korea/epidemiology;
Tetracycline/pharmacology
- From:The Korean Journal of Gastroenterology
2011;57(4):221-229
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions of Korea. METHODS: H. pylori were isolated from gastric mucosal biopsy specimens of 99 Koreans who lived in Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) from April to August in 2008. All the patients had no history of H. pylori eradication therapy. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin, and moxifloxacin were tested according to the agar dilution method. RESULTS: There was a difference in resistance to clarithromycin in three institutes located among Gyeonggi (32.5%), Kangwon province (12.5%) and Busan (42.1%) by One way ANOVA test (p=0.027) and nonparametric Kruskal Wallis test (p=0.027). However, by post-hoc analysis, there was no statistically significant difference among three regions. Similarly, the other 7 antibiotics (amoxicillin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin) did not show any significant difference. CONCLUSIONS: There was no significant regional difference of the primary antibiotic resistance of H. pylori. However, the included patient number might not be enough for this conclusion demanding further evaluations.
