A Case of Rifampin Induced Hemolytic Anemia Combined with Thrombocytopenia and Acute Renal Failure.
- Author:
Chiseon KO
1
;
Kye Chul KWON
;
Jong Woo PARK
;
Sun Hoe KOO
;
So Yeon SHIN
Author Information
1. Department of Laboratory Medicine, Chungnam National University Hospital, Daejeon, Korea. kckwon@cnu.ac.kr
- Publication Type:In Vitro ; Case Report
- Keywords:
Rifampin;
Hemolytic anemia;
Thrombocytopenia;
Acute renal failure
- MeSH:
Acute Kidney Injury*;
Adult;
Anemia, Hemolytic*;
Antigen-Antibody Complex;
Blood Urea Nitrogen;
Coombs Test;
Creatinine;
Female;
Humans;
Leukocyte Count;
Nausea;
Oliguria;
Platelet Count;
Rifampin*;
Thrombocytopenia*;
Vomiting
- From:Korean Journal of Blood Transfusion
2007;18(1):56-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 35 year old woman was admitted to the hospital owing to her nausea, vomiting, oliguria and petechia with re-administration of rifampin. Laboratory tests were performed and they showed a hemoglobin level of 8.6 g/dL, a leukocyte count of 7,660/microliter, a platelet count of 1,000/microliter, a blood urea nitrogen level of 92.3 mg/dL and a creatinine level of 10.6 mg/dL. The Direct Coombs' test and anti-platelet antibody test were positive. Hemolytic anemia combined with thrombocytopenia and acute renal failure related to rifampin was suspected. We proved the formation of immune complex with anti-rifampin antibody and rifampin by in vitro testing. Hemolytic anemia combined with thrombocytopenia and acute renal failure after treatment with rifampin is a rare condition. We report here on such a case along with a brief review of the related literature.
