Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer's disease.
- Author:
Ji Jing YAN
1
;
Won Gyun AHN
;
Jun Sub JUNG
;
Hee Sung KIM
;
Md Ashraful HASAN
;
Dong Keun SONG
Author Information
- Publication Type:Original Article
- Keywords: Alzheimer disease; Acanthopanax divaricatus; beta-amyloid peptide; amyloid precursor protein/presenilin 1
- MeSH: Eleutherococcus*; Acetylcholine; Administration, Oral; Alzheimer Disease*; Amyloid; Animals; Brain; Glial Fibrillary Acidic Protein; Hippocampus; Interleukins; Malondialdehyde; Mice*; Plaque, Amyloid
- From:Nutrition Research and Practice 2014;8(4):386-390
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS: We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of beta-amyloid peptide (Abeta) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice. RESULTS: Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of Abeta1-42 until evaluation) effectively blocked Abeta1-42-induced impairment in passive avoidance performance, and Abeta1-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-1alpha in the hippocampus. In addition, it alleviated the Abeta1-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1beta in the brain. CONCLUSIONS: The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.
