A Case of Goodpasture's Syndrome in a Foundry Worker.
- Author:
Min Gi KIM
1
;
Dong Hee KOH
;
Sun Wong LEE
;
Min Heui JO
;
Hee Yong YOO
;
Bo Yeon KIM
;
June Hyuk LEE
Author Information
1. Occupational Safety & Health Research Institute Korea Safety & Health Agency, Korea. godong21@daum.net
- Publication Type:Case Report
- Keywords:
Goodpasture's syndrome;
Silica;
Foundry worker
- MeSH:
Anti-Glomerular Basement Membrane Disease;
Antibodies, Antineutrophil Cytoplasmic;
Autoantibodies;
Biopsy;
Bronchoscopy;
Chest Pain;
Cough;
Crystallins;
Dyspnea;
Glomerulonephritis;
Granuloma;
Hematuria;
Hemorrhage;
Humans;
Hydrocarbons;
Kidney;
Lung;
Middle Aged;
Occupational Health;
Plasmapheresis;
Proteinuria;
Renal Dialysis;
Respiratory Tract Infections;
Risk Factors;
Silicon Dioxide;
Smoke;
Smoking;
Threshold Limit Values;
Tobacco Products;
Urea;
Vasculitis
- From:Korean Journal of Occupational and Environmental Medicine
2008;20(1):46-53
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Smoking, upper respiratory tract infection, genetic factors and hydrocarbons are known as risk factors of Goodpasture's syndrome. We studied a patient with Goodpasture's syndrome who had worked for 27 years in a foundry company. Based on a study on the work-relatedness of the syndrome, we describe and discuss our study results. CASE: A 46-year-old man, who had worked as a foundry worker for 27 years and had a 12 1/2 packyear history of smoking cigarettes, was admitted into a hospital on 15th February 2006 with coughing, chest pain and dyspnea. On admission, he had hematuria, proteinuria, severe restrictive pulmonary function disorder and rapid elevation of blood urea nitrogen/creatinine. Immunological examination showed ANA (+), ANCA (-) and Anti-GBM Ab (+). Kidney biopsy showed pauci-immune crescentic glomerulonephritis. Mild bleeding was revealed through bronchoscopy and no vasculitis and granuloma were present on at lung biopsy. Finally, we diagnosed the worker's illness as Goodpasture's syndrome and carried out hemodialysis and plasmapheresis. In the workplace survey, the exposure level of respirable crystalline silica exceeded the TLV-TWA (0.0106 mg/m3), which was calibrated for overtime. CONCLUSION: Based on both the clinical test and industrial hygiene examination, we concluded that the Goodpasture's syndrome in this case was caused by long-term silica exposure.
