A Case of Chronic Granulomatous Disease Which is Improved by Interferon- Therapy.
- Author:
Jae Choon KIM
1
;
Soon Seong PARK
;
Myung Ja YUN
;
Dong Hyuk KEUM
Author Information
1. Department of Pediatrics, Kangbuk Samsung Hospital, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Chronic granulomatous disease;
Interferon- therapy
- MeSH:
Anemia;
Body Surface Area;
Granuloma;
Granulomatous Disease, Chronic*;
Humans;
Hypergammaglobulinemia;
Injections, Subcutaneous;
Interferon-gamma;
Liver Abscess;
Metabolism;
Phagocytes
- From:Journal of the Korean Pediatric Society
1997;40(7):1021-1025
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis.We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient's NBT test was less than 11%. The patient received subcutaneous injection of interferon-gamma, 200 million unit (0.1mg/m2 of body surface area per dose), on three consecutive days per week for 3 weeks and her symptom was improved. Then, we report a case of chronic granulomatous disease which is improved by interferon- therapy with brief review of literature.
