Preceding Annular Skin Lesions in a Patient with Hemophagocytic Lymphohistiocytosis.
- Author:
Hee Jin JUN
1
;
Hyung Ok KIM
;
Jun Young LEE
;
Young Min PARK
Author Information
- Publication Type:Case Report
- Keywords: Annular skin lesions; Hemophagocytic lymphohistiocytosis
- MeSH: Adult; Biopsy; Bone Marrow; Diagnosis; Drug Therapy; Fever; Humans; Hypertriglyceridemia; Lymphohistiocytosis, Hemophagocytic*; Pancytopenia; Skin*
- From:Annals of Dermatology 2015;27(5):608-611
- CountryRepublic of Korea
- Language:English
- Abstract: The cutaneous manifestations of hemophagocytic lymphohistiocytosis (HLH) are variable and nonspecific. A 42-year-old man presented with multiple annular, erythematous patches on the trunk for 3 months. Two months later, he presented with bullae along with high fever. The laboratory examination showed pancytopenia, hypertriglyceridemia, and hypofibrinogenemia. The bone marrow biopsy specimen showed an active hemophagocytosis. On the basis of these findings, a diagnosis of HLH was concluded. After five cycles of chemotherapy, his skin lesion completely resolved. Taking the results together, we suggest that annular skin lesion can be added to the list of cutaneous manifestations of HLH.
