Concurrent Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas with Pre-Existing Intrinsic Chronic Inflammation: A Case Report and a Review of the Literature.
- Author:
Sooyeon OH
1
;
Nayoung KIM
;
Dong Hyun OH
;
Soo Mee BANG
;
Yoon Jin CHOI
;
Ju Yub LEE
;
Kyung Won LEE
;
Ho Il YOON
;
Hee Chul YANG
;
Jin Ho PAIK
;
Dong Ho LEE
;
Hyun Chae JUNG
Author Information
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't ; Review
- Keywords: Stomach; Lung; Lymphoma, B-cell, marginal zone
- MeSH: Aged; Gastric Mucosa/pathology; Humans; Inflammation/pathology; Lung Neoplasms/etiology/*pathology; Lymphoma, B-Cell, Marginal Zone/etiology/*pathology; Male; Respiratory Mucosa/pathology; Stomach Neoplasms/etiology/*pathology; Tuberculosis, Pulmonary/complications
- From:Gut and Liver 2015;9(3):424-429
- CountryRepublic of Korea
- Language:English
- Abstract: Herein, we report a rare case of concurrent gastric and pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas. A 65-year-old man who had been diagnosed with Helicobacter pylori-positive gastric MALT lymphoma received eradication therapy and achieved complete remission. During follow-up, he developed de novo pulmonary MALT lymphoma as a sequela of pulmonary tuberculosis, accompanied by recurrent gastric MALT lymphoma. Polymerase chain reaction (PCR) products of the CDR3 region of the immunoglobulin heavy chain gene showed an overall polyclonal pattern with bands at 400 base pairs (bp) and 200 bp predominant in the pulmonary tissue, as well as two distinctive bands in the gastric tissue at 400 bp and 200 bp. This case suggests that multiorgan lymphomas are more likely to be independent from each other when they are far apart, involve different organ systems, and have independent precipitating factors.
