Proliferative Effect of Retinal Glial Cells by Growth Factors.
- Author:
Nam Chun CHO
1
;
Min Cheol LEE
;
Hong Joo HAN
;
Byeong Gook AHN
Author Information
1. Department of Ophthalmology, Chonbuk National University, Medical School, Chonju.
- Publication Type:Original Article
- Keywords:
Growth Factor;
Astrocyte;
Retinal Injury
- MeSH:
Astrocytes;
Bromodeoxyuridine;
Cell Proliferation;
Culture Media, Serum-Free;
Epidermal Growth Factor;
Humans;
Insulin-Like Growth Factor I;
Intercellular Signaling Peptides and Proteins*;
Neuroglia*;
Retina;
Retinaldehyde*
- From:Journal of the Korean Ophthalmological Society
1997;38(7):1179-1187
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The authors tried to evaluate the effect of the growth factors on cell proliferation in the human retina astrocyte culture. Each growth factor, EGF, bFGF, GGF, IGF-1 or PDGF, together with BrdU was added to astrocytes-enriched cultures in the serum-free media. The proliferating effect of each growth factor was evaluated by a double immunofluo- rescenece labelling for GFAP and BrdU. By and addition of each growth factor, the number of retinal astrocytes at the synthetic stage significantly increased than those of control group (p<0.01). In comparision, PDGF was more potent than IGF-1 (p<0.01). Above data extended the concept of astrocytic proliferation caused by several growth factors in human retinal injury.
