A Case of Primary Sclerosing Cholangitis with Ulcerative Colitis.
- Author:
Kyu Won CHUNG
;
Hee Sik SUN
;
Doo Ho PARK
;
Kyu Yong CHOI
;
Soo Heon PARK
;
Joon Yeol HAN
;
Se Hyun CHO
;
Won Hee HAN
;
Chang Suk KANG
- Publication Type:Case Report
- Keywords:
Ulcerative colitis;
Primary sclerosing cholangitis
- MeSH:
Adult;
Alkaline Phosphatase;
Bacteria;
Bile Ducts, Extrahepatic;
Bile Ducts, Intrahepatic;
Biopsy;
Chemistry;
Cholangiopancreatography, Endoscopic Retrograde;
Cholangitis, Sclerosing*;
Colitis, Ulcerative*;
Colon;
Colonoscopy;
Dizziness;
Europe;
Gastrointestinal Hemorrhage;
Humans;
Incidence;
Inflammation;
Korea;
Liver;
Prevalence;
Ulcer*
- From:Korean Journal of Gastrointestinal Endoscopy
1996;16(6):1001-1007
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sclerosing cholangitis is cholestatic disease, characterized by progressive fibrotic inflammation and obliteration af intrahepatic bile ducts and extrahepatic bile ducts and sometimes associated with ulcerative colitis. The pathogenesis of this disease is not understood well. In this disease, however, have been proposed infectious agent, endotoxin of bacteria and immunological event. In Europe and U.S.A., the incidence of sclerosing cholangitis associated with ulcerative colitis was between 2,4 and 4.0 percent. The association is strongest in patients with pancolitis, with a prevalenee of 5.5 percent, compared with patients with disease confined to the distal colon, with a prevalence of 0.5 percent. But, in Korea, it has not been reported sclerosing cholangitis associated with ulcerative colitis. A 30-year old man was diagnosed as an ulcerative colitis 9 years ago and has been followed up, intermittently. Recently, he has experienced hematochezia and dizziness. Colonoscopy showed active ulcerative colitis(pancolitis), blood chemistry elevated alkaline phosphatase and y-GTP. ERCP and liver biopsy specimen revealed sclerosing cholangitis. we concluded that this case was a sclerosing cholangitis as a complication of ulcerative colitis and the first case report of primary sclerosing cholangitis with ulcerative colitis in Korea, Hence, we reported a case of primary sclerosing cholangitis with ulcerative colitis with a review of literatures.
