A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome.
- Author:
Nan Yee KYE
1
;
Kon Hee LEE
;
Jae Kook CHA
;
Hye Sun YOON
;
Won Keun SONG
Author Information
1. Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Congenital acute megakaryoblastic leukemia;
Down syndrome
- MeSH:
Biopsy;
Blood Platelets;
Bone Marrow;
Dacarbazine;
Down Syndrome*;
Glycoproteins;
Hemorrhage;
Humans;
Leukemia, Megakaryoblastic, Acute*;
Megakaryocyte Progenitor Cells;
Primary Myelofibrosis
- From:Journal of the Korean Pediatric Society
1997;40(4):578-583
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein III a receptor. On third hospital day, the patient expired due to DIC and pulmonary hemorrhage. Authors report the case with review of literature.
