Association of acute tubular necrosis with gross hematuria in cirrhosis-related immunoglobulin A nephropathy.
- Author:
Jang Soo HAN
1
;
So Dug LIM
;
Won Hyeok CHOI
;
Sung Chul HONG
;
Jung Hee PARK
;
Eugene PARK
;
Mi Jin HONG
;
Cho I LEE
;
Jung Hwan PARK
;
Jong Ho LEE
;
Jong Oh SONG
;
Young Il JO
Author Information
1. Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. nephjo@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Cirrhosis;
Hematuria;
Lamivudine;
Renal failure
- MeSH:
Acute Kidney Injury;
Erythrocytes;
Fibrosis;
Glomerulonephritis, IGA;
Hematuria;
Hepatitis B;
Humans;
Immunoglobulin A;
Immunoglobulins;
Lamivudine;
Necrosis;
Renal Insufficiency;
Renal Replacement Therapy
- From:Kidney Research and Clinical Practice
2013;32(1):43-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
Immunoglobulin A (IgA) nephropathy associated with cirrhosis is the most common form of secondary IgA nephropathy (IgAN). Cirrhosis-related IgAN is usually clinically silent with a rare occurrence of gross hematuria, unlike in cases of idiopathic IgAN. Especially, acute tubular necrosis (ATN) associated with gross hematuria is very rare in cirrhosis-related IgAN, although acute renal failure is a frequently reported complication in advanced cirrhosis. Herein, we report an unusual case of ATN requiring renal replacement therapy, associated with gross hematuria in a patient with nonalcoholic, hepatitis B virus-associated cirrhosis. Results of a histopathological analysis revealed obstruction of the lumen of renal tubules by red blood cell casts, a marked tubular necrosis, and IgA deposition in the mesangium. The patient's renal function and gross hematuria were clearly improved after lamivudine treatment.
