Effect of Bovine and Human Lactoferrin on MA 104 Cell Infected with Human Rotavirus.
- Author:
Kwang Jong CHA
1
;
Dae Yeul YU
;
Chong Kee LEE
;
Jae Hyeun YU
Author Information
1. School of Animal Life Science, College of Animal Husbandry, Konkuk University.
- Publication Type:Original Article
- Keywords:
Lactoferrin;
Human rotavirus;
Hydrolysed Lactoferrin;
Digestive enzymes
- MeSH:
Humans*;
Lactoferrin*;
Rotavirus Infections;
Rotavirus*
- From:Journal of the Korean Society of Virology
1999;29(2):87-97
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It has long been known that lactoferrin prevents human beings from infection of virus. To prove this activity of lactoferrin, we evaluated the activities of different lactoferrins to an isolate human rotavirus K-21. Bovine lactoferrin inhibited infection of K-21 to MA-104 cell at the concentration of 25.9 microM whereas bovine hydrolysed lactoferrin prevented rotavirus infection at 103.8 microM. However human lactoferrin prevented infection of K-21 at the concentration of 217.5 microM. These data suggested that lactoferrin activity may be unaffected by the intestinal digestive enzymes and bovine lactoferrin is more active than human lactoferrin with respect to prevention of rotavirus infection.
