Survival Analysis of the Children with Down Syndrome.
- Author:
Jung Sun KIM
1
;
In Kyu KIM
;
Jin Seop KANG
;
Eun Kyung LEE
;
Bo Kyung KIM
;
Kyu Hyung LEE
;
Seo Jeong KIM
;
Hyung Gon KANG
;
Chung Woong KAY
;
Hee Jung AHN
Author Information
1. Department of Pediatircs, College of Medicine, Pochon CHA University, Pochon, Korea.
- Publication Type:Original Article
- MeSH:
Cause of Death;
Child*;
Down Syndrome*;
Follow-Up Studies;
Heart Defects, Congenital;
Humans;
Kaplan-Meier Estimate;
Leukemia;
Life Expectancy;
Mortality;
Seoul;
Survival Analysis*
- From:Korean Journal of Perinatology
1999;10(3):338-344
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine the life expectancy and causes of death of the children with Down syndrome(DS), longitudinal follow-up study was done for 29 cases of DS who were born at CHA hospital located in Seoul During the period from July 1991 to Dec. 1994. METHODS: 29 cases were divided into groups according to the presence of congenital heart disease (CHD) and leukemia. CHD group was subdivided into DS with complete AVSD(atrioventricular septal defect) and DS without complete AVSD. Survival curves were calculated by kaplan-Meier product limit method. Each group were compared by log rank test. The factors affecting mortality rate were analyzed by Cox's proportional hazard regressional model. RESULTS: There were no statistical differences in mortality rate between groups with CHD(35.3%) and without CHD(33.3%)(p=0.7373). Statistical difference was not observed between CHD subgroups with AVSD and with CHD other than AVSD. There were significant statistical difference in mortality rate between groups with leukemia and without leukemia(p=0.0001). CONCLUSION: The factor affecting mortality rate of DS was the presence of leukemia regardless of presence of CHD in our study cases with DS.
