Changes of Serum Interleukin-6 & Interleukin-10 in Vertebrobasilar Insufficiency.
- Author:
Kwang Taek JI
1
;
Bong Goo YOO
;
Ji Hyun LEE
;
Min Jeong KIM
;
Kwang Soo KIM
Author Information
1. Department of Neurology, Kosin University College of Medicine, Busan, Korea. ybgne@ns.kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Vertebrobasilar insufficiency;
Interleukin-6;
Interleukin-10
- MeSH:
Cytokines;
Enzyme-Linked Immunosorbent Assay;
Humans;
Infarction;
Interleukin-10*;
Interleukin-6*;
Stroke;
Stroke, Lacunar;
Vertebrobasilar Insufficiency*
- From:Journal of the Korean Geriatrics Society
2005;9(2):138-145
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: A few studies have revealed increased levels of certain cytokines in patients with ischemic stroke. Cytokine changes have not been studied in patients with transient ischemic attack(TIA). The purpose of this study was to evaluate the temporal profile of the inflammatory response in patients with vertebrobasilar insufficiency (VBI) and to compare the inflammatory response between TIA and infarction through analyzing serum interleukin(IL)-6 and IL-10. METHODS: We serially measured the serum levels of IL-6 and IL-10 in 14 patients with VBI, 12 patients with vertebrobasilar territoy infarction, and 21 patients with lacunar infarction at the timing of admission, at 1 day after symptom onset, and at 5 day after symptom onset. Cytokines were measured by sandwich ELISA method. RESULTS: The IL-6 level obtained at day 1 was significantly elevated compared with the normal control group in patients with TIA (p<0.05). The IL-6 level at day 1 was the highest in patients with VBI. The level of IL-10 in patients with VBI was significantly higher than normal group at all time points(p<0.05). The IL-10 level at the timing of admission was the highest in patients with VBI. But the serum levels of IL-6 and IL-10 between VBI and vertebrobasilar territory and lacunar infarction groups did not show any differences. CONCLUSION: These findings show that pro- and anti-inflammatory cytokines in serum are elevated in patients with TIA. These results suggest that cytokine cascade occurs in TIA.
