The Effect of Salbutamol and Budesonide Inhalation Therapy in Infants with Bronchiolitis.
- Author:
Jae Hee PARK
1
;
Jae Bum LEE
;
Kyong Tae WHANG
;
Ji Hee CHO
;
Kyong Og KO
;
Yun Duk YOO
Author Information
1. Department of Pediatrics, Sun General Hospital, Taejeon, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Bronchiolitis;
Salbutamol;
Budesonide;
Clinical Score
- MeSH:
Albuterol*;
Bronchiolitis*;
Budesonide*;
Daejeon;
Diagnosis;
Follow-Up Studies;
Humans;
Infant*;
Inhalation*;
Length of Stay;
Nebulizers and Vaporizers;
Oxygen;
Respiratory Rate;
Respiratory Sounds;
Respiratory Therapy*;
Retrospective Studies;
Solar System;
Ultrasonics
- From:Journal of the Korean Pediatric Society
1997;40(1):45-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this trial was to determine whether salbtamol and budesonide combined inhalation therapy is more efficacious than conservative treatment for admitted infants with bronchiolitis in early phase. METHODS: The study subjects were 72 infants admitted to Sun Hospital in Taejeon from July 1994 to June 1995, whose age from 1 month to 12 months with clinical diagnosis of bronchiolitis. Infants were randomly assigned to different three treatment groups as follw: Group C: 21 infants who received conservative treatment with oxygen (4liter/min); Group A: 23 infants who received salbutamol (0.1mg/kg) inhalation therapy using ultrasonic nebulizer at 6 hours interval add to conservative therapy; Group B: 28 infants who received budesonide (0.1mg/kg) inhalation therapy with above mentioned treatment at 12 hours interval. Then, infants were analyzed by comparison of clinical score, repiratory rate at time order of entry, 12 hours, 24 hours, 48 hours, 72 hours, and 5 days after treatment. We also compared ABGA of admission time to 24 hours after treatment of all groups and appreciate total hospital days of three groups. On follow up, same analyzing methods of comparison were used on 42 non-recurrent wheezing infants. RESULTS: The mean values of clinical score and respiratory rate were significantly improved in salbutamol and budesonide inhalation treatment group at 24 hours from medium of 6.1 60.7/min to 2.4, 42.3/min respectly. This effect was sustained thereafter. On the while, salbutamol inhalation group was significantly improved the clinical score and respiratory reate at 12 hours after therapy, but thereafter there was no obvious difference to conservative treatment. After then we exclude the recurrent infants and analyzed above mentioned items retrospectively. The improvement of clinical score and respiratory rate of salbutamol and budesonide inhalation therapy group was significant. Oxygenation was improved after 24hours of salbutamol and budesonide inhalation therapy. Total hospital stay was significantly reduced in salbutamol and budesonide inhalation group, and slightly reduced inthe salbutamol inhalation group. CONCLUSION: Infants with bronchiolitis treated with salbutamol and budesonide inhalation achieved better results in clinical score, repiratory rate PO2, and hospital days than no inhalation therapy. No reapiratory failure was occurred. So, this trial as treatment of bronchiolitis may be useful and effective therapy in those infants.
