No evidence of association between interleukin-13 gene polymorphism in aspirin intolerant chronic urticaria.
- Author:
Nami Shrestha PALIKHE
1
;
Seung Hyun KIM
;
Gil Soon CHOI
;
Young Min YE
;
Hae Sim PARK
Author Information
- Publication Type:Original Article
- Keywords: aspirin; IL-13; urticaria
- MeSH: Alleles; Aspirin; Gene Frequency; Genotype; Haplotypes; Humans; Immunoglobulin E; Interleukin-13; Interleukins; Phenotype; Polymorphism, Genetic; Risk Factors; Urticaria
- From:Allergy, Asthma & Immunology Research 2009;1(1):36-40
- CountryRepublic of Korea
- Language:English
- Abstract: Aspirin-intolerant chronic urticaria (AICU) is a common condition among the chronic urticaria population, but the genetic mechanism is not yet understood. In this study, the genotypes and haplotypes of three interleukin (IL)-13 polymorphisms, -1510 A>C, -1055C>T, and Arg110Gln (110G>A), as well as their respective clinical phenotypes were examined to determine whether genetic variants of IL-13 play a role in AICU. Single-nucleotide polymorphism (SNP) genotyping was used to compare IL-13 genotype and allele frequencies among 135 patients with AICU, 146 with aspirin-tolerant chronic urticaria (ATCU), and 430 normal controls (NC). Relationships among the AICU phenotype, atopy, and total IgE level were also investigated. The results failed to show a significant difference in the allele or genotype frequencies between the AICU group and either the ATCU or NC group (P>0.05, respectively). Haplotype analysis confirmed that there was no significant difference among the three study groups (P>0.05), nor was there a significant difference in atopy or total IgE level according to the three genetic polymorphisms (P>0.05, respectively). Our data lead to the conclusion that there is no evidence supporting genetic polymorphisms in IL-13 as a genetic risk factor for the development of AICU.
