Clostridium difficile Colitis after Topical Ophthalmic Use of Levofloxacin.
10.12771/emj.2013.36.S.S5
- Author:
Jang Wook LEE
1
;
Seong Yong WOO
;
Suk Joon PARK
;
Seung Hyun HONG
;
Sung Yun LEE
;
Seung Min WOO
Author Information
1. Department of Internal Medicine, Daerim Saint Mary's Hospital, Seoul, Korea. loveandy@hanmail.net
- Publication Type:Case Report
- Keywords:
Clostridium difficile;
Enterocolitis;
Levofloxacin;
Ophthalmic solutions
- MeSH:
Absorption;
Aged;
Anti-Bacterial Agents;
Cataract;
Centers for Disease Control and Prevention (U.S.);
Clostridium difficile*;
Clostridium*;
Colitis*;
Enterocolitis;
Female;
Humans;
Levofloxacin*;
Ophthalmic Solutions;
Plasma;
Running
- From:The Ewha Medical Journal
2013;36(Suppl):S5-S8
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Clostridium difficile colitis (CDC) has been associated with virtually all available antibiotics. It is well known that administration of drugs by the ocular route can result in systemic absorption with the possibility of systemic effect. We report a case of a 74-year-old woman who was treated with 0.5% levofloxacin eyedrops for ten weeks running for the post operative management of two separate bilateral cataract surgeries. Toxin assay for C. difficile was positive and the endoscopic findings were compatible with CDC. The plasma concentrations reached after intraocular administration of levofloxacin seem so trivial, but the administration of topical agents could make accumulated effect and be a potential cause of systemic toxicity.
