Radiation Recall Dermatitis Induced by Gefitinib.
10.12771/emj.2013.36.S.S17
- Author:
Beodeul KANG
1
;
Ah Young LEEM
;
Young Jae KIM
;
Eudong HWANG
;
Yujung YUN
;
Sun Wook KIM
;
Hyo Song KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. hyosong77@yuhs.ac
- Publication Type:Case Report
- Keywords:
Gefitinib;
Lung cancer;
Radiation recall dermatitis;
Radiation therapy
- MeSH:
Erythema;
Female;
Humans;
Lung Neoplasms;
Middle Aged;
Neoplasm Metastasis;
Protein-Tyrosine Kinases;
Radiodermatitis*;
Receptor, Epidermal Growth Factor;
Skin;
Small Cell Lung Carcinoma;
Spine
- From:The Ewha Medical Journal
2013;36(Suppl):S17-S21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Radiation recall dermatitis refers to an acute inflammatory reaction in a previously irradiated field triggered by the administration of certain drugs days to years after the exposure to radiation. Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor and is an effective treatment for patients with advanced stage of non small cell lung cancer (NSCLC). Here, we report a rare case of gefitinib induced radiation recall dermatitis. A 52-year-old woman with a metastatic NSCLC had received a palliative radiation therapy of 20 cGy on spine metastasis area (C6-T6). After 24 days of receiving radiation therapy, she had started to take gefitinib. Eight months after taking drug, pain, swelling and erythema of skin were occurred on previously irradiated field. These symptoms were resolved after the cessation of gefitinib for 6 days and the topical use of steroid.
