Clinical Remission of Renal Amyloidosis after Autologous Peripheral Blood Stem Cell Transplantation.
10.12771/emj.2013.36.S.S25
- Author:
Seong Yeong AN
1
;
Yon Hee KIM
;
Young Eun KWON
;
Yung Ly KIM
;
Ki Heon NAM
;
Heun CHOI
;
Young Ju KIM
;
Kyoung Sook PARK
;
Hyeon Joo JEONG
;
Hyung Jung OH
;
Jung Tak PARK
;
Seung Hyeok HAN
;
Shin Wook KANG
;
Tae Hyun YOO
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. yoosy0316@yuhs.ac
- Publication Type:Case Report
- Keywords:
AL amyloidosis;
Hematopoietic cell transplantation;
Melphalan
- MeSH:
Amyloid;
Amyloidosis*;
Arterioles;
Biopsy;
Bone Marrow Examination;
Capillaries;
Cell Transplantation;
Congo;
Edema;
Electrophoresis;
Female;
Humans;
Hyperlipidemias;
Hypoalbuminemia;
Immunoglobulin M;
Melphalan;
Microscopy, Electron;
Middle Aged;
Multiple Myeloma;
Nephrotic Syndrome;
Paraproteinemias;
Peripheral Blood Stem Cell Transplantation*;
Plaque, Amyloid;
Prognosis;
Proteinuria;
Transplants
- From:The Ewha Medical Journal
2013;36(Suppl):S25-S29
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary amyloidosis has unfavorable prognosis, particularly with organ involvement. Here, we report a case of clinical remission of renal amyloidosis after autologous hematopoietic cell transplantation. A 51-year-old female patient visited our hospital due to generalized edema. Initial evaluation showed hyperlipidemia, hypoalbuminemia, and heavy proteinuria, which were consistent with nephrotic syndrome. However, IgM lamda type monoclonal gammopathy was detected in serum and urine electrophoresis studies. Renal biopsy showed Congo red-positive amyloid deposition in mesangial area, glomerular capillary walls, and arterioles and amyloid fibers were confirmed by electron microscopy. Immunohistochemial study of the biopsy tissue demonstrated systemic light-chain amyloidosis (AL amyloidosis). Multiple myeloma was not evident on bone marrow examination. She received autologous hematopoietic cell transplantation after high dose melphalan treatment. Complete remissions were achieved after the treatment, respectively. Our findings suggest the potential role of autologous peripheral blood stem cell transplantation in treatment of AL amyloidosis.
