The Molecular Pathogenesis of Pituitary Adenomas: An Update.
10.3803/EnM.2013.28.4.245
- Author:
Xiaobing JIANG
1
;
Xun ZHANG
Author Information
1. Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xzhang5@mgh.harvard.edu
- Publication Type:Review
- Keywords:
Pituitary neoplasms;
Oncogenes;
Tumor suppressors;
Cell cycle;
MicroRNAs
- MeSH:
Brain Neoplasms;
Cell Cycle;
Cell Transformation, Neoplastic;
Epigenomics;
Genes, Tumor Suppressor;
MicroRNAs;
Oncogenes;
Pituitary Hormones;
Pituitary Neoplasms*
- From:Endocrinology and Metabolism
2013;28(4):245-254
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development of satisfactory treatment for pituitary adenomas. Although the pathogenesis of pituitary adenomas is largely unknown, considerable evidence indicates that the pituitary tumorigenesis is a complex process involving multiple factors, including genetic and epigenetic changes. This review summarized the recent progress in the study of pituitary tumorigenesis, focusing on the role of tumor suppressor genes, oncogenes and microRNAs.
