Five Cases of Hemorrhagic Disease of Infancy.
- Author:
Jung Sook MOON
1
;
Eun Hee KOH
;
Sang Man SHIN
;
Sang Jhoo LEE
Author Information
1. Department of Pediatrics, Soon Chun Hyang College, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Osteopetrosis;
Malignant;
R4esponsive to prednisolone;
Hemorrhagic disease;
infancy;
Vitamin K
- MeSH:
Anti-Infective Agents;
Blood Coagulation Factors;
Diarrhea;
Diet;
Epistaxis;
Hemorrhage;
Hemothorax;
Humans;
Infant;
Intracranial Hemorrhages;
Osteopetrosis;
Prothrombin;
Prothrombin Time;
Purpura;
Vitamin K;
Vitamin K Deficiency
- From:Journal of the Korean Pediatric Society
1982;25(5):518-522
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A hemorrhagic disease due to acquired prothrombin complex deficiency is presented in five infants from 3 weeks to 2 months of age. There are 2 cases of intracranial hemorrhage, 1 case of hemothorax, 2 cases of gastrointestinal bleeding, 1 case of epistaxis and 3 cases of petechia, purpura or bleeding from injection site. After the administration of vitamin K, bleeding ceased and prolonged prothrombin time was corrected promptly. Vitamin K dependent coagulation factor deficiency due to vitamin K deficiency is accounted for the pathogenesis of bleeding. Diarrhea, treatment with antimicrobial agents and a diet low in vitamin K are suggested as etiologic factors acting together.
