Effects of Drugs on the Interaction of Calcium and Cardiac Muscle Memberane Fragments.
- Author:
Doo Hee KANG
1
;
Joong Woo LEE
;
Kyu Sik CHUNG
Author Information
- Publication Type:Original Article ; In Vitro ; Research Support, Non-U.S. Gov't
- Keywords: Cardiac muscle membrane; calcium ion; cardioactive drugs
- MeSH: Anesthetics, Local/pharmacology*; Animal; Calcium/metabolism*; Cardiotonic Agents/pharmacology*; Cell Membrane/metabolism; In Vitro; Myocardium/metabolism*
- From:Yonsei Medical Journal 1982;23(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: The effect of drugs on calcium-binding to cardiac muscle membrane fragments and its turnover rate was studied. Ouabian, acetylcholine, isoproterenol and norepinephrine did not have any effect either on calcium-binding to membrane fragments or an washout ahnd release curves of previously bound calcium. Local anesthetics inhibited the calcium-binding. Tetracaine at concentrations of 1 and 10 mM inhibited the calcium-binding by 30% and 54%, respectively, while 10 mM lidocaine inhibited it by 17%. Propranolol, a well-known adrenergic beta-blocker, also inhibited calcium-binding at the external calcium concentration of 10(-3) M. This effect of propranolol may be attributed to its local anesthetic-like action, rather than to the adrenergic blocking effect.
