Effect of Renal Insufficiency on Stone Recurrence in Patients with Urolithiasis.
10.3346/jkms.2014.29.8.1132
- Author:
Ho Won KANG
1
;
Sung Phil SEO
;
Won Tae KIM
;
Yong June KIM
;
Seok Joong YUN
;
Sang Cheol LEE
;
Wun Jae KIM
Author Information
1. Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea. lscuro@chungbuk.ac.kr
- Publication Type:Original Article ; Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Urinary Calculi;
Recurrence;
Renal Insufficiency;
Creatinine
- MeSH:
Aged;
Causality;
Disease-Free Survival;
Female;
*Glomerular Filtration Rate;
Humans;
Incidence;
Male;
Middle Aged;
Recurrence;
Renal Insufficiency/*diagnosis/*epidemiology;
Reproducibility of Results;
Republic of Korea/epidemiology;
Risk Assessment;
Sensitivity and Specificity;
Urolithiasis/*diagnosis/*epidemiology
- From:Journal of Korean Medical Science
2014;29(8):1132-1137
- CountryRepublic of Korea
- Language:English
-
Abstract:
The study was designed to assess the relationship between glomerular filtration rate (GFR) and urinary stone-forming constituents, and to assess the effect of renal insufficiency on stone recurrence risk in first stone formers (SF). Baseline serum creatinine levels were obtained, and renal insufficiency was defined as creatinine clearance < or =60 mL/min (Cockroft-Gault). This retrospective case-control study consists of 342 first SF; 171 SF with normal renal function were selected with 1:1 propensity scores matched to 171 SF with renal insufficiency. Urinary metabolic evaluation was compared to renal function. GFR was positively correlated with urinary calcium, uric acid, and citrate excretion. Subjects with renal insufficiency had significantly lower urinary calcium, uric acid, and citrate excretion than those with normal renal function, but not urine volume. With regard to urinary metabolic abnormalities, similar results were obtained. SF with renal insufficiency had lower calcium oxalate supersaturation indexes and stone recurrence rates than SF with normal renal function. Kaplan-Meier curves showed similar results. In conclusion, GFR correlates positively with urinary excretion of stone-forming constituents in SF. This finding implies that renal insufficiency is not a risk factor for stone recurrence.
