Acute Pancreatitis Induced by Methimazole Treatment in a 51-Year-Old Korean Man: A Case Report.
10.3346/jkms.2014.29.8.1170
- Author:
Jung Hwa JUNG
1
;
Jong Ryeal HAHM
;
Jaehoon JUNG
;
Soo Kyoung KIM
;
Sungsu KIM
;
Kyong Young KIM
;
Bo Ra KIM
;
Hong Jun KIM
;
Yi Yeong JEONG
;
Sun Joo KIM
Author Information
1. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. jrhahm@hanmail.net
- Publication Type:Case Reports
- Keywords:
Methimazole;
Graves Disease;
Pancreatitis;
Drug-Related Side Effects and Adverse Reactions
- MeSH:
Abdominal Pain/*chemically induced/diagnosis;
Acute Disease;
Diagnosis, Differential;
Fever of Unknown Origin/*chemically induced/diagnosis;
Graves Disease/*drug therapy;
Humans;
Male;
Methimazole/*adverse effects/*therapeutic use;
Middle Aged;
Pancreatitis/*chemically induced/diagnosis;
Treatment Outcome
- From:Journal of Korean Medical Science
2014;29(8):1170-1173
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves' disease. There was no evidence of agranulocytosis, and fever subsided soon after stopping MMI treatment. However, 5 hr after taking an additional dose of MMI, abdominal pain and fever developed again. His symptoms, biochemical, and imaging studies were compatible with acute pancreatitis. After withdrawal of MMI, he showed clinical improvement. This is the first case of MMI-induced acute pancreatitis in Korea. Clinicians should be aware of the rare but possible MMI-induced pancreatitis in patients complaining of fever and abdominal pain.
