Osteoclast-like Giant Cell Tumor of the Parotid Gland Accompanied with Carcinoma ex Pleomorphic Adenoma.
10.4132/KoreanJPathol.2011.45.S1.S84
- Author:
Mi Jung KWON
;
Eun Sook NAM
;
Seong Jin CHO
;
Hyung Sik SHIN
;
Ji Hyun KWON
;
Young Soo RHO
- Publication Type:Case Report
- Keywords:
Giant cell tumor;
Parotid gland;
Mixed tumor, malignant;
Osteoclasts;
Monocytes
- MeSH:
Adenoma, Pleomorphic;
Aged;
Cytosine;
Female;
Giant Cell Tumors;
Giant Cells;
Humans;
Korea;
Mixed Tumor, Malignant;
Monocytes;
Osteoclasts;
Parotid Gland;
Salivary Glands;
Stromal Cells
- From:Korean Journal of Pathology
2011;45(Suppl 1):S84-S88
- CountryRepublic of Korea
- Language:English
-
Abstract:
The origin of osteoclast-like giant cell tumor (OGCT) of the salivary gland has been debated because the prototypic cells of osteoclast-like cells and mononuclear stromal cells are largely unexplained in this gland. Bone marrow-derived CD14+ and CD45+ monocyte-derived multipotential cells (CD14+/CD45+ MOMC) may be one of the possible origins of OGCTs of salivary glands, which have never been explored in salivary OGCTs. We present a case of OGCT accompanied with carcinoma ex pleomorphic adenoma in the parotid gland of a 67-year-old Korean female. The tumor presented as a rapidly growing cervical mass comprising a central area of carcinoma ex pleomorphic adenoma and a peripheral circumferential area of OGCT. The immunohistochemical staining pattern was phenotypically consistent with bone marrow-derived CD14+/CD45+ MOMC. This case is the first report of a salivary OGCT in Korea.
