The Expressions of Matrix Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinase-1 in Scar Endometriosis and Full Term Endometrium.
- Author:
Chang Ho CHO
1
;
Suk Bong KOH
Author Information
1. Department of Pathology, School of Medicine Catholic University of Daegu.
- Publication Type:Original Article
- Keywords:
Endometriosis;
Endometrium;
Abdominal scar;
MMP-9;
TIMP-1
- MeSH:
Cicatrix*;
Endometriosis*;
Endometrium*;
Female;
Matrix Metalloproteinase 9*;
Tissue Inhibitor of Metalloproteinase-1
- From:Korean Journal of Obstetrics and Gynecology
2002;45(8):1311-1316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Endometriosis in a surgical scar following cesarian section is rare condition. And its pathogenesis has not been well established. The purpose of this study is to observe the expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-1 (TIMP-1) in scar endometriosis and full term endometrium during cesarian section. METHODS: Nineteen scar endometriotic tissue and ten full term pregnant endometrium during cesarian section were investigated by immunohistochemical stain for MMP-9 and TIMP-1. RESULTS: The MMP-9 was expressed in eleven of nineteen scar endometriotic tissue (57.9%) and eight of ten full term pregnant endometrium (80.0%). The TIMP-1 was not expressed in both scar endometriotic tissue and full term pregnant endometrium. CONCLUSION: These results suggest that the relationship between MMP-9 and TIMP-1 might play a role of pathogenesis of scar endometriosis.
