The Effects of Low Dose Estrogen Replacement Therapy on the Lipid Profile of Postmenopausal Women.
- Author:
Heung Yeol KIM
1
;
Wan Kyu EO
Author Information
1. Department of Obstetrics and Gynecology, School of Medicine, Kosin university, Busan, Korea.
- Publication Type:Clinical Trial ; Original Article ; Randomized Controlled Trial
- Keywords:
Low dose conjugated equine estrogen;
Lipid profile
- MeSH:
Cholesterol;
Cholesterol, HDL;
Cholesterol, LDL;
Estrogen Replacement Therapy*;
Estrogens*;
Female;
Humans;
Prospective Studies;
Triglycerides
- From:Korean Journal of Obstetrics and Gynecology
2002;45(8):1360-1366
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the effects of low dose estrogen replacement therapy on the lipid profile in the postmenopausal women. METHODS: This prospective randomized clinical trial examined the effects of low dose conjugated equine estrogen on lipid profile in 140 postmenopausal women. Treatment included 0.625 mg conjugated equine estrogen (group I, n=75), or 0.31mg conjugated equine estrogen (group II, n=55) for 12 months. Lipid profile were performed at months 6 and 12 months. RESULTS: HDL cholesterol increased significantly during the treatment in Group I and Group II. LDL cholesterol decreased significantly during the treatment in Group I and Group II. Total cholesterol in Group I and Group II decreased during treatment, but not significantly. As triglyceride increased slightly during the treatment in Group I and Group II but not significantly. CONCLUSION: The low dose conjugated equine estrogen is also positive changes on lipid profile.
