Effect of 5-Fluorouracil and Methotrexate on the Glaucoma Filtering Surgery.
- Author:
Hai Gon KIM
1
;
Ill Han YOON
;
Sae Heun RHO
Author Information
1. Department of Ophthalmology, Paik Hospital, Inje College, Pusan, Korea.
- Publication Type:Original Article
- MeSH:
Cicatrix;
Fibroblasts;
Filtering Surgery*;
Fluorouracil*;
Gelatin Sponge, Absorbable;
Glaucoma*;
Intraocular Pressure;
Methotrexate*;
Optic Nerve;
Trabeculectomy
- From:Journal of the Korean Ophthalmological Society
1988;29(3):347-351
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of glaucoma filtering surgery is to maintain low intraocular pressure that do not damage to the optic nerve. The failure of filtering surgery commonly result from scarring process at filtering site. 5-Fluorouracil and methotrexate are anti metabolites capable of inhibiting fibroblast proliferation. We aim to evaluate the inhibitory effect of the 5-fluorouracil and methotrexate subconjunctival injection into gelfoam, embeded suibconjunctivally over trabeculectomy site in the rabbit. In our experimental study, we observed that 5-fluorouracil and methotrexate inhibit the fibroblast proliferation in filtering site by light microscope. So, we report this result with a brief review of literatures.
