An Immunopathologic Studies in Fixed Drug Eruption.
- Author:
Jae Hong KIM
;
Chang Woo LEE
;
Kyu Uang WHANG
;
Joong Hwan KIM
- Publication Type:Original Article
- Keywords:
Fixed drug eruption;
HLA - DR antigen
- MeSH:
Antibodies;
Antibodies, Monoclonal;
Biopsy;
Dermis;
Drug Eruptions*;
Epidermis;
Extracellular Space;
Fibrin;
Fluorescence;
Fluorescent Antibody Technique, Direct;
Humans;
Immunoglobulin G;
Skin;
T-Lymphocytes
- From:Korean Journal of Dermatology
1986;24(2):232-237
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Biopsy specimens taken from the active lesional skin of five patients with fixed drug eruption were studied to examine the deposit of immunoreactants and to characterize the cells infiltrated in the tissue. The direct immunofluorescence showed the deposition of cytoid bodies and fibrin around the dermoepidermal interface in all five pztients, A deposition of IgG in the intercellular space of epidermis was also noted in one patient, however the intensity of fluorescence was not strong. The indirect immunoperoxidase staining using monoclonal antibodies showed that about ppg, of dermal infiltrates reacted with anti-pan-T cell(OKT11), and the ratio of OKT4a reactive clls to OKT8A reactive cells among the desmal infiltrates was approximately 1: 1. OKT.8A reactive cytotoxic T cells were found not only in the dermis but also in the dermoepidermal interface and occasionally in the epidermis. The fact that most(over 80%) of the dermal infiltrat,es were reactive with aint-HLA-DR antibodies, suggests that the T cell mediated cellular immune mechanism could be involved in large extent in the pathogenesis of fixed drug eruption.
