Effect of Splenic Artery Interruption on Complete Blood Count Profiles in Living Donor Liver Transplant Recipients.
- Author:
Wan Joon KIM
1
;
Deok Bog MOON
;
Jeong Ik PARK
;
Shin HWANG
;
Ki Hun KIM
;
Chul Soo AHN
;
Tae Yong HA
;
Gi Won SONG
;
Dong Hwan JUNG
;
Kwan Woo KIM
;
Nam Kyu CHOI
;
Gil Chun PARK
;
Young Dong YU
;
Pyung Jae PARK
;
Young Il CHOI
;
Kun Moo CHOI
;
Sung Gyu LEE
Author Information
1. Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Korea. sglee2@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Splenic artery;
Interruption;
Ligation;
Embolization;
Living donor liver transplantation
- MeSH:
Aneurysm;
Blood Cell Count;
Blood Platelets;
Hepacivirus;
Humans;
Ligation;
Liver;
Liver Transplantation;
Living Donors;
Neutrophils;
Pancytopenia;
Platelet Count;
Retrospective Studies;
Rupture;
Spleen;
Splenectomy;
Splenic Artery;
Tokyo;
Transplants
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2009;13(4):242-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Splenectomy during living donor liver transplantation (LDLT) in a hepatitis C virus (HCV)-related cirrhotic recipient was performed by a Tokyo group to enhance the patient's tolerability to post-operative anti-viral treatment by improving complete blood count (CBC) profiles. At our institution, interruption of the splenic artery (SPA) by ligation or embolization in lieu of splenectomy, has been performed in LDLT to modulate portal blood flow in small-for-size graft LDLT or to prevent rupture of SPA aneurysms in recipients. We aimed to determine if interruption of the SPA can serve as an alternative management to splenectomy in LDLT recipients based on our data. METHODS: Patients were classified into the splenic artery ligation group (SAL; n=26) and splenic artery embolization group (SAE; n=19), respectively. Among the recipients without SPA interruption, age-, gender-, and severity of cirrhosis-matched 25 recipients were selected as a control group. Post-operative CBC profiles and spleen size were reviewed retrospectively and compared between the groups. RESULTS: After SAL, platelet and neutrophil counts were significantly increased at 3 and 6 months, and at 1 week and 1 month, respectively (p<0.05). After SAE, platelet and neutrophil counts were significantly increased at 3 and 6 months, and at 1 week and 3 months, respectively. There were no significant complications related to interruption of the SPA. CONCLUSION: Interruption of the SPA may have a role in improving neutrophil and platelet counts in LDLT recipients with severe pancytopenia or in whom antiviral treatment for HCV in anticipated.
