Myelomatous effusion with poor response to chemotherapy.
10.3346/jkms.2000.15.2.243
- Author:
Young Min KIM
1
;
Kuk Kyung LEE
;
Hung Ssok OH
;
Sung Kyu PARK
;
Jong Ho WON
;
Dae Sik HONG
;
Hee Sook PARK
;
Jai Soung PARK
;
Dong Wha LEE
Author Information
1. Department of Internal Medicine, Soonchunhyang University, College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Multiple Myeloma;
Pleural Effusion;
Drug Therapy
- MeSH:
Antineoplastic Agents, Combined/administration & dosage*;
Case Report;
Cyclophosphamide/administration & dosage;
Female;
Human;
Melphalan/administration & dosage;
Middle Age;
Multiple Myeloma/pathology;
Multiple Myeloma/drug therapy*;
Multiple Myeloma/complications*;
Plasma Cells/pathology;
Pleural Effusion/radiography;
Pleural Effusion/pathology;
Pleural Effusion/etiology*;
Prednisone/administration & dosage;
Tomography, X-Ray Computed;
Vincristine/administration & dosage
- From:Journal of Korean Medical Science
2000;15(2):243-246
- CountryRepublic of Korea
- Language:English
-
Abstract:
While pleural effusion in multiple myeloma is relatively infrequent, myelomatous pleural effusion is extremely rare. We experienced a 61-year-old woman with IgD-lambda multiple myeloma and pleural effusion. The diagnosis was made originally by pleural biopsy, pleural fluid cytology and immunoelectropheresis of pleural fluid. Transient improvement of the pleural effusion was observed after administration of combination chemotherapy of vincristine, melphalan, cyclophosphamide, prednisone (VMCP)/vincristine, cyclophosphamide, adriamycin, prednisone (VCAP). Two months later, myelomatous pleural effusion recurred and no response to salvage therapy was observed. We reviewed the clinical feature of this case and literature concerning myelomatous pleural effusion.
