Mental Disorders in Offspring of Parents with Bipolar Disorder.
10.4306/jknpa.2014.53.5.310
- Author:
Young Sung CHO
1
;
Hwa Young LEE
;
Young Joon KWON
;
Hee Yeun JEONG
;
Jung Yi SHIN
;
Se Hoon SHIM
Author Information
1. Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Korea. shshim2k@daum.net
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
Offspring;
Child;
Adolescent
- MeSH:
Adolescent;
Anxiety Disorders;
Bipolar Disorder*;
Child;
Heredity;
Humans;
Korea;
Mental Disorders*;
Mood Disorders;
Nuclear Family;
Parents*;
Prevalence;
Psychopathology;
Sensitivity and Specificity
- From:Journal of Korean Neuropsychiatric Association
2014;53(5):310-319
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Information on the specificity of associations between parents with bipolar disorder (BPD) and risk of psychopathology in their offspring is limited. The aim of this study was to examine the prevalence of mental disorders in the offspring of individuals with BPD in South Korea. METHODS: The sample consisted of 100 child and adolescent offspring (aged 6.0-18.9 years) from 65 nuclear families having at least one parent with BPD. Probands, offspring, and biological co-parents were interviewed using a semi-structured diagnostic interview and the offspring were evaluated using the Korean version of the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). RESULTS: Sixty one of the 100 participants met the criteria for at least one mental disorder. Of these, 35 participants had a mood disorder, 35 had an anxiety disorder, and 29 had attention-deficit hyperactivity disorder (ADHD). Thirty nine of the offspring had no psychiatric diagnosis. Of the 35 with a mood disorder, 16 (45.7%) had comorbid ADHD and 18 (51.4%) had comorbid anxiety disorders. CONCLUSION: Offspring of parents with BPD are at high risk for mental disorders. These findings further support the heredity of BPD and indicate the need for early identification and treatment.
