Benefits of a Continuous Ambulatory Peritoneal Dialysis (CAPD) Technique with One Icodextrin-Containing and Two Biocompatible Glucose-Containing Dialysates for Preservation of Residual Renal Function and Biocompatibility in Incident CAPD Patients.
10.3346/jkms.2014.29.9.1217
- Author:
Hye Eun YOON
1
;
Yoon Kyung CHANG
;
Seok Joon SHIN
;
Bum Soon CHOI
;
Byung Soo KIM
;
Cheol Whee PARK
;
Ho Cheol SONG
;
Sun Ae YOON
;
Dong Chan JIN
;
Yong Soo KIM
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. kimcmc@catholic.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Biocompatibility;
Peritoneal Dialysis, Continuous Ambulatory;
Icodextrin, Randomized Controlled Trial;
Residual Renal Function
- MeSH:
Adult;
Aged;
CA-125 Antigen/analysis;
Creatinine/urine;
Dialysis Solutions/*therapeutic use;
Female;
Glomerular Filtration Rate;
Glucans/*therapeutic use;
Glucose/*therapeutic use;
Humans;
Interleukin-6/analysis;
Kidney/physiopathology;
Kidney Failure, Chronic/*therapy;
Male;
Membrane Proteins/analysis;
Middle Aged;
Peritoneal Dialysis;
Peritoneal Dialysis, Continuous Ambulatory;
Urea/urine
- From:Journal of Korean Medical Science
2014;29(9):1217-1225
- CountryRepublic of Korea
- Language:English
-
Abstract:
In a prospective randomized controlled study, the efficacy and safety of a continuous ambulatory peritoneal dialysis (CAPD) technique has been evaluated using one icodextrin-containing and two glucose-containing dialysates a day. Eighty incident CAPD patients were randomized to two groups; GLU group continuously using four glucose-containing dialysates (n=39) and ICO group using one icodextrin-containing and two glucose-containing dialysates (n=41). Variables related to residual renal function (RRF), metabolic and fluid control, dialysis adequacy, and dialysate effluent cancer antigen 125 (CA125) and interleukin 6 (IL-6) levels were measured. The GLU group showed a significant decrease in mean renal urea and creatinine clearance (-Delta1.2+/-2.9 mL/min/1.73 m2, P=0.027) and urine volume (-Delta363.6+/-543.0 mL/day, P=0.001) during 12 months, but the ICO group did not (-Delta0.5+/-2.7 mL/min/1.73 m2, P=0.266; -Delta108.6+/-543.3 mL/day, P=0.246). Peritoneal glucose absorption and dialysate calorie load were significantly lower in the ICO group than the GLU group. The dialysate CA125 and IL-6 levels were significantly higher in the ICO group than the GLU group. Dialysis adequacy, beta2-microglobulin clearance and blood pressure did not differ between the two groups. The CAPD technique using one icodextrin-containing and two glucose-containing dialysates tends to better preserve RRF and is more biocompatible, with similar dialysis adequacy compared to that using four glucose-containing dialysates in incident CAPD patients. [Clincal Trial Registry, ISRCTN23727549]
