Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.
- Author:
Nguyen Huu TUNG
1
;
Takuhiro UTO
;
Osamu MORINAGA
;
Yukihiro SHOYAMA
Author Information
1. Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan. shoyama@niu.ac.jp
- Publication Type:Original Article
- Keywords:
Bupleurum falcatum;
Umbellifeae;
Quinic acid;
Saikosaponin;
Anti-proliferative activity
- MeSH:
Bupleurum*;
Cell Line;
Flavonoids;
Glycosides;
Quinic Acid
- From:Natural Product Sciences
2015;21(2):71-75
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4 - 8), three monoterpene glycosides (9 - 11), and three saikosaponins (12 - 14). Compound 1 was first isolated from nature and unambiguously determined to be 3-O-feruloyl 5-O-caffeoylquinic acid on the basis of the extensive spectroscopic evidence. Biological testing revealed that saikosaponin A (12) and saikosaponin D (13) showed moderate antiproliferative effects on HL-60 and HepG2 cancer cell lines.
