A Case Report of Mantle Cell Lymphoma in Leukemic Phase.
- Author:
Mi Won HWANG
;
Hyun Kyung CHOI
;
Soo Young YOON
;
Ae Rhee KIM
;
Kap No LEE
- Publication Type:Case Report
- MeSH:
Biopsy;
Bone Marrow;
Cytoplasm;
Germinal Center;
Humans;
Leukemia, B-Cell;
Leukemia, Lymphocytic, Chronic, B-Cell;
Leukemia, Prolymphocytic;
Lymph Nodes;
Lymphatic Diseases;
Lymphocytes;
Lymphocytosis;
Lymphoma, Follicular;
Lymphoma, Mantle-Cell*;
Male;
Membranes;
Middle Aged;
Phenotype
- From:Korean Journal of Clinical Pathology
1997;17(4):539-546
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recently, we experienced a patient with a B cell leukemia which could not be classified as chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PL) or follicular lymphoma in leukemic phase. He is a 58-year-old male and suffered from progressive lymphadenopathy at both inguinal and cervical areas. His blood film showed lymphocytosis (79%), and the cells were heterogeneous in size and shape. Twenty-five percent of the lymphocytes had nuclear irregularities or cleavages unlike the lymphocytes of CLL In which the cells often shows monomorphic features, small size with scanty cytoplasm and round nucleus. The bone marrow trephine biopsy specimen showed a diffuse pattern of infiltration of atypical Iymphoid cells. The lymph node histology showed atypical lymphoid colls proliferated as wide mantles around non-neoplastic appearing germinal centers. The immunophenotype of circulating lymphocytes in peripheral blood showed strong reactivity with CD5, CDl9 and CD20 without expression of CD2, CD3, CD7, CD10, CD22 and CD23. Although this case resembled CLL, the laboratory features showed major differences, notably in the Peripheral blood morphology, histology Patterns and the membrane Phenotype. By combining these data, we diagnosed this case as a leukemic phase of mantle cell lymphoma.
